The Interrelationship Between the Systems of the Human Body
This essay will consider the structure and function of the 11 systems within the human body. It will detail the interrelationship between the nervous system and the musculoskeletal system and between the circulatory system and the lymphatic system. It will then explain the roles of the circulatory and lymphatic systems in the immune response and the role of hormones in metabolism.
Human Body Systems
The human body is made up of 11 separate but interconnected systems (Sherwood, 2007). These are the skeletal, muscular, circulatory, respiratory, digestive, excretory, nervous, integumentary, immune, endocrine and reproductive systems. The success and survival of the human body is dependent on the ability of separate body systems to work together.
The skeletal system provides structure for the human body, stores minerals, produces blood cells and provides protection for delicate organs (Kelly, 2004). 206 bones are connected with ligaments, muscles and tendons, with cartilage, a softer cushion like material, providing protection in jointed areas. Body movements are controlled by the muscular system, with these muscles being connected to bones via tendons (Adams, 2004). Stimulation of these muscles by the nervous system causes contraction and the resulting movement of bones to which they are attached. A number of involuntary muscles ensure the respiratory and circulatory systems continue with contraction of the heart and lungs (Adams, 2004). The heart is central to the circulatory system and acts as to pump blood through arteries, veins and capillaries. The circulatory system is responsible for delivering nutrients and oxygen to cells as well as removing waste products and aiding the immune system through the circulation of white blood cells (Jacab, 2006). The immune system is comprised of lymph organs, such as the spleen and thymus, and the skin, all of which are responsible for protecting the body against invading pathogens (Parham, 2005).
The circulatory system and the respiratory system are closely interconnected with the latter bringing fresh oxygen into the body through the alveoli of the lungs (Johnson, 2004). The respiratory system is closely connected with the excretory system as it is responsible for the removal of carbon dioxide and other waste gases through exhalation. The excretory system eliminates both solid and liquid wastes in addition to these gaseous products, and is made up of a number of specialist tissues along with the large intestine, bladder, kidneys, rectum, lungs and skin (Sherwood, 2007). The physical and chemical breakdown of food into energy is carried out by the digestive system. This system commences with the mouth, teeth and salivary glands then passes through the oesophagus to the stomach and small intestine for digestion. The liver, pancreas and large intestine are also involved, through the production of digestive enzymes and bile and the processing of nutrients (Windelspecht, 2004).
The nervous system is responsible for sending messages to and from the brain through neurons. The nervous system controls all bodily functions by sending electrochemical signals through the neural network (Llamas, 1998). The endocrine system acts as a communication network but uses hormones as chemical messengers which travel through the bloodstream (Klosterman, 2009). The hormones have specific target organs and carry signals to start or stop performing a specific function. Finally, the reproductive system is responsible for the production of children and reproductive hormones cause our bodies to develop into sexual maturity.
Relationship between the nervous and musculoskeletal system
Muscle is a contractile tissue that can be histologically divided into three types. These are: striated or skeletal muscle, which are under direct nervous control; cardiac muscle, which is also striated but is a specialist form that is confined specifically to the heart; and smooth or visceral muscle, which is not under direct nervous control (Nair and Peate, 2013). This latter form can be found in the walls of blood vessels and the alimentary tract and in arrector pili. Smooth muscle is usually in the form of flat sheets and forms circular and longitudinal layers, or can be arranged as a sphincter in order to control passage through a tube, for example the anus (Ikebe, 1996). Skeletal muscle is usually attached to two separate bones via tendon, fleshy or aponeurosis connections.
Muscle action control is carried out by the nervous system (Stein, 1982). Contact between nerves and muscles often occurs through chemical stimulus conveyed by motor end plates, which instruct muscles to contract. Signals can also be sent through tendons via specific receptors that are able to measure the stretch of the tendon (Stein, 1982). Messages from nerves are referred to as efferent when they take a message to a specific tissue and afferent when they are taking the message to the spinal cord and brain (Craig, 2005). As such the nervous system comprises two separate but combined systems. These are the central and peripheral nervous systems, with the former being made up of the brain and spinal cord, and the latter comprising the remaining neural network (Cervero, 1988). This neural network comprises 12 pairs of head nerves connected to the brain and 31 pairs of spinal nerves connected to the spinal cord. Nerves which transfer information from receptors within the body to the central nervous system are sensoric nerves, whilst nerves that transport information from the CNS to muscle fibres are motoric nerves (Cervero, 1988). As such, the peripheral nervous system comprises collections of nerves, their insulating myelin sheaths, Schwann cells and connective tissue. The majority of these nerve cells are able to carry out efferent and afferent cell processes (Craig, 2005).
Figure 1 shows the organisation of a neuron, with the body being the axon and the smaller projections being known as dendrites. The neuron uses the dendrites to obtain and pass information from and to other neurons (Spruston, 2008). The axon passes the information to other cells particularly muscle cells. The information is then passed along the neuron through voltage changes within the cell membrane. This is known as the action potential (Bean, 2007). Information transfer between individual nerve cells occurs through chemical agents which are released when the action potential has reached the end of an axon.
Relationship between the circulatory and lymphatic systems
These systems primarily comprise of the body's blood circulating and waste removal capabilities. The two systems are significantly intertwined and work collectively to transport substances throughout the body (Sherwood, 2007). Both systems work in a similar manner as they both produce a liquid substance, either lymph or blood, which flows through a network of vessels and ducts to reach every part of the body. Both of these liquid substances are responsible for carrying nutrients or removing waste and are therefore both circulatory in nature (Sherwood, 2007).
The primary role of the circulatory system is the transport of blood throughout the body. It comprises the heartand a network of veins, arteries and capillaries that move oxygenated blood to the body’s tissues and deoxygenated blood and waste products away from body tissues (Johnson, 2004). This crucial blood transport system carries nutrients, oxygen and fluids throughout the body, which are needed for normal cell activity.
The primary role of the lymphatic system is waste removal. When muscles absorb unneeded material, lymph fluid picks up this waste product and transports it to the lymph nodes (Cueni and Detmar, 2006). This system is responsible for eliminating old red blood cells, which means that the lymphatic system is effectively the circulatory system’s waste disposal unit. Blood plays a major role in the creation of lymph as blood plasma develops into interstitial fluid after contact with body tissues (Wu et al, 2013). Some of this interstitial fluid enters the lymphatic vessels where it develops into lymph. As such, one of the major responsibilities of the lymphatic system is to act as a drain for the interstitial fluid surrounding tissues. This clear fluid is carried through the lymphatic vessels into lymphatic ducts and through lymph nodes where lymphocytes attack foreign bodies and pathogens (Alitalo et al, 2005). After passing through these areas, the lymph passes into the large brachiocephalic or subclavian veins and re-enters the circulatory system.
Role of the circulatory and lymphatic system in the immune response
Whilst the circulatory system is responsible for the transport of blood, oxygen and nutrients to the cells of the body, it is also often responsible for the carriage of bacteria and other pathogens throughout the body. The lymphatic system isa crucial part of the body's immune response to these pathogenic invasions (Bajenoff et al, 2007). Lymphoid tissue, which is found in a number of organs, specifically in the lymph nodes and in lymphoid follicles that are associated with the digestive system, including the tonsils, contains lymphocytes. The lymphatic system also includes bone marrow, the thymus and the spleen, along with other dedicated circulatory and lymphocyte production structures (Bajenoff et al, 2007). There are two types of lymphocyte with the first type being responsible for directly attacking any invading pathogen and the second type being responsible for the production of antibodies that then circulate within the bloodstream and attack any further invading pathogens (Bajenoff et al, 2007). Any invading foreign particle or pathogen is picked up by the lymph and transported through the lymph vessels to the regional lymph nodes. Within these lymph nodes, dendritic cells and macrophages phagocytose the antigens, before processing them and presenting these foreign antigens to the lymphocytes (Wei et al, 2003). These lymphocytes then produce antibodies or act as memory cells, which are responsible for recognising specific antigen attacks in the future, thereby improving the speed of the immune response. As such, the lymphatic system can be described as a system responsible for both transport and defence. Figure 2 shows a diagram of the human lymphatic system showing the network of lymph nodes and connecting lymphatic vessels.
Role of hormones in the metabolic process
In order to control nutrient intake, store any excess and utilise the stores when necessary, a number of hormones are used. Insulin and glucagon are the two primary hormones responsible for maintaining blood glucose homeostasis, additional regulation is also mediated by thyroid hormones (Patel et al, 2008). Beta cells of the pancreas produce insulin after stimulation from a rise in blood glucose levels. Insulin is responsible for lowering blood glucose levels by increasing the rate of glucose uptake and by encouraging target cells to use this glucose for the production of ATP. The liver is also stimulated to convert glucose to glycogen with the latter being stored for later use. Glucose transport proteins are incorporated into cell membranes when insulin bind to these target cells via receptors and through signal transduction (Patel et al, 2008). This method allows for the transport of glucose into the cell where it can be used as a source of energy. This results in the lowering of blood glucose concentrations which then results in a negative feedback loop and inhibits further insulin release from the beta cells.
When blood glucose levels drop below normal levels, usually between meals or when glucose is being utilised through exercise, the pancreas releases the hormone glucagon (Patel et al, 2008). Glucagon is responsible for raising blood glucose levels through eliciting the hyperglycemic effect. This is the breakdown of glycogen to glucose within the liver cells and skeletal muscle in a process known as glycogenolysis. This free glucose can then be utilised as energy by the muscle cells whilst the liver releases glucose into circulation for use by other key organs (Patel et al, 2008). Glucagon also stimulates the liver to absorb amino acids from the blood, with this organ then being responsible for conversion of these amino acids to glucose. This synthesis of glucose is named gluconeogenesis (Patel et al, 2008). Any rise above normal levels in blood glucose levels is also controlled buy a negative feedback loop with any further release of glucagon by the pancreas being halted. Therefore, homeostatic glucose levels are controlled by insulin and glucagon working together.
- Adams, A. (2004). The muscular system. Westport, CT: Greenwood Press.
- Alitalo, K., Tammela, T., & Petrova, T. V. (2005). Lymphangiogenesis in development and human disease. Nature, 438(7070), 946-953.
- Bajénoff, M., Egen, J. G., Qi, H., Huang, A. Y., Castellino, F., & Germain, R. N. (2007). Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node. Trends in Immunology, 28(8), 346-352.
- Bean, B. P. (2007). The action potential in mammalian central neurons. Nature Reviews Neuroscience, 8(6), 451-465.
- Biomedical Engineering (2016). Biomedical Advances: Neuron Damage. [online] Available at: http://biomedicalengineering.yolasite.com/neurons.php [Accessed 2 Feb. 2016].
- Cervero, F. (1988). Organization of the autonomic nervous system — Central and peripheral mechanisms. Pain, 33(3), p.390.
- Craig, A. (2005). Forebrain emotional asymmetry: a neuroanatomical basis? Trends in Cognitive Sciences, 9(12), pp.566-571.
- Cueni, L. N., & Detmar, M. (2006). New insights into the molecular control of the lymphatic vascular system and its role in disease. Journal of Investigative Dermatology, 126(10), 2167-2177.
- Ikebe, M. (1996). Contractile Mechanisms: Biochemistry of Smooth Muscle Contraction. Science, 274(5286), pp.367b-368b.
- Jakab, C. (2006). The circulatory system. North Mankato, MN: Smart Apple Media.
- Johnson, R. (2004). Respiration and circulation. Washington, D.C.: National Geographic.
- Kelly, E. (2004). The skeletal system. Westport, CT: Greenwood Press.
- Klosterman, L. (2009). Endocrine system. New York: Marshall Cavendish Benchmark.
- Llamas, A. (1998). The nervous system. Milwaukee, Wis.: Gareth Stevens Pub.
- Nair, M. and Peate, I. (2013). Fundamentals of applied pathophysiology. Chichester, West Sussex: Wiley-Blackwell.
- Parham, P. (2005). The immune system. New York: Garland Science.
- Patel, S., Doble, B. W., MacAulay, K., Sinclair, E. M., Drucker, D. J., & Woodgett, J. R. (2008). Tissue-specific role of glycogen synthase kinase 3β in glucose homeostasis and insulin action. Molecular and Cellular Biology,28(20), 6314-6328.
- Sherwood, L. (2007). Human physiology. Australia: Thomson/Brooks/Cole.
- Spruston, N. (2008). Pyramidal neurons: dendritic structure and synaptic integration. Nature Reviews Neuroscience, 9(3), 206-221.
- Stein, R. (1982). What muscle variable(s) does the nervous system control in limb movements? Behavioral and Brain Sciences, 5(04), p.535.
- Wei, S. H., Parker, I., Miller, M. J., & Cahalan, M. D. (2003). A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunological Reviews, 195(1), 136-159.
- Windelspecht, M. (2004). The digestive system. Westport, CT.: Greenwood Press.
- Wu, M., Frieboes, H. B., McDougall, S. R., Chaplain, M. A., Cristini, V., & Lowengrub, J. (2013). The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems. Journal of Theoretical Biology, 320, 131-151.