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Type 2 diabetes mellitus is a heterogenous syndrome with polygenic origin. Type 2 diabetes mellitus involves both defective insulin secretion and peripheral insulin resistance (1). There is a progressive deterioration in β-cell function over time regardless of the type of therapy. Pancreatic islets are found to be at 50% of normal functional capacity at time of diagnosis; reduction in function is generally found 10 to 12 years before diagnosis (2). Cases of diabetes mellitus 2 are increasing in the developed world; the center for disease control and prevention has characterized this increase as an epidemic (3)....