The Sustained Release Bilayer Tablets Of Ambroxol Hydrochloride Biology Essay

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Ramana G et al., formulated and evaluated the sustained release bilayer tablets of Ambroxol hydrochloride. The tablets were prepared by direct compression technique using sodium starch glycolate as super disintegrant for fast release layer and SR grade polymers such as HPMC K4M , Ethyl cellulose independently and also in combinations. The formulation containing Drug:HPMC:EC at the ratio of 1:0.5:30% exhibited an initial burst effect followed by sutained release over a period of 12 hours. The dissolution data of various formulations were fitted into Higuchi and Peppas models, which are linear with Higuchi's plot and "n" values obtained from Peppas were within 0.45 to 0.89 indicate the mechanism of drug release diffusion coupled with erosion.

Brijesh patel et al., designed and evaluated mucoadhesive controlled release oral bilayer tablets of indomethacin. Solid dispersion of indomethacin were prepared using PEG 6000 to improve the solubility of indomethacin. Bilayer tablets were prepared using direct compression technique employing Ac-Di-Sol as super disintegrant for immediate release layer and Carbopol 934 LR, HPC for sustained release layer. The polymers were used alone or in combinations. By varying the concentrations of polymers several batches were formulated. The batch containg the mixture of Carbapol 934 LR and HPC in the ratio of 1:1 showed a better drug release than individual formulation containing carbapol 934 LR and HPC.the drug release kinetics was studied and it was found that the drug was released from the formulation by diffusion.

Deelip derle et al., formulated and evaluated buccoadhesive bilayer tablets of propranolol hydrochloride. The tablets were prepared by direct compression method. Bioadhesive polymers such as sodium alginate and Carbapol 971P were used and ethyl cellulose was used as an impermeable backing layer. The tablets were prepared in two steps, initially the drug polymer mixture was compressed after that the backing layer of ethyl cellulose was placed over the compact and then compressed into bilayer tablets. Tablets containing sodium alginate and Carbapol 971P in the ratio of 5:1 showed the maximum percentage of invitro release without disintegration for 12 hours. The mechanism of drug release was found to follow zero-order kinetics.

Nagaraju R et al., formulated and evaluated bilayer sustained release tablets of Salbutamol and Theophylline. Wet granulation technique was employed for preparation of granules. PVP K 30 in isopropyl alcohol was used as a binder. Various polymers such as HPMC K4M, HPMC K100M, xanthan gum, ethyl cellulose and HPMC-P were studied. HPMC-P and HPMC K4M were found to be best in controlling the release.

Ashish A Pahade et al., Designed and developed bilayer sustained release tablets of Isosorbide mononitrate. Wet granulation technique was employed for preparing granules using PVP K30 as binder. The immediate release granules were prepared using croscarmellose sodium as super disintegrant. Hydrophilic and hydrophobic matrix materials such as HPMC K4M and Polyox WSR 303 was used for preparing sustained release layer. The influence of hydrophilic and hydrophobic polymer and granulation technique was studied. By varying the concentrations of HPMC K4M four formulations of bilayer tablets were prepared. The formulation containing HPMC K4M at a concentration of 19.33%w/w was selected as the optimized batch as it showed better Invitro release profile compared to other batches. Similarly by varying the concentration of hydrophobic polymer Polyox WSR 303 three batches of bilayer tablets were prepared. The formulation containing 15%w/w showed better Invitro release profile and thus it was optimized for further studies.

Bhavesh Shiyani et al., Formulated and evaluated bilayer tablets of Metoclopramaide hydrochloride(MTH) and Ibuprofen(IB). MTH was formulated as immediate release layer by using various disintegrants like Ac-Di-Sol, Polyplasdone XL, Explotab, Agar and Gellan Gum. The formulation containing Ac-Di-Sol was optimized for preparing Bilayer tablets. Sustained release layer of IB was formulated using hydrophilic matrix HPMC K4M, buffering agent sodium bicarbonate and PVP K30. By increasing the concentrations of HPMC K4M and PVP K30 the release was reduced. By inclusion of buffering agent sodium bicarbonate the release was icreased as well as there is reduction in gastric irritation as IB is a weak acid. The drug release mechanism was found to be Quasi-fickian diffusion.

Narendra.C et al., studied the optimization of bilayer floating tablets of Metoprolol succinate. A 23 factorial design was used for optimizing the formulation with respect to polymer-drug (X1), polymer-polymer (X2) and different viscosity grades of s polymer ratio(x3) as independent variables. Four dependent variables are percentage of drug release at 8 hours, t50%, diffusion coefficient and floating time. X1 and X2 significantly affected the floating time and release properties, but the effect of different viscosity grades of HPMC K4M and HPMC K100M was not significant.

Vinoth kumar.G et al., formulated and evaluated bilayered tablets of cefixime trihydrate and dicloxacillin sodium. Wet franulation technique was used to formulate granules for both the layers. Cefixime trihydrate was formulated as immediate release layer using cross caramellose sodium as superdisintegrant. Sustained release layer of dicloxacillin sodium was formulated by varying the concentrations of HPMC K4M and HPMC K100M. 9 batches of bilayer tablets were prepared. All the formulations were compared with the innovator product in respect to all tablet properties such as hardness, friability, disintegration time and dissolution. The percentage drug release of formulation F5 showed drug release comparable to the innovator product disintegration time and drug release and thus it was optimized and kept for further studies.

Gohel MC et al., fabricated and evaluated bilayer tablets containing conventional paracetamol and modified release Diclofenac sodium. A 23full factorial design was adopted using the amount of polyethylene glycol, microcrystalline cellulose and crospovidone as independent variables for fabricating paracetamol tablets. Diclofenac sodium tablets were prepared using varying concentrations of HPMC K4M as matrixing agent. The results of analysis of variance showed that the friability of paracetamol was distinctly influenced by the formulation variables. Diclofenac sodium layer was optimized by comparing the formulation with the innovator product. The optimized layers were finally compressed into bilayer tablets. The tablets were subjected for drug release mechanism. It was found out that the bilayer tablets followed korsmeyer-Peppas model.

Naeem MA et al., developed and evaluated controlled release bilayer tablets containing microencapsulated tramadol and acetaminophen. Microencapsulation based phase separation technique using medium viscosity ethyl cellulose was employed to formulate separate microparticles for extending the release of both drugs. The microparticles of both the drugs were prepared separately and were used for formulating the bilayer tablets. The optimized batches were subjected for studying the release mechanism. The release kinetics was followed by Higuchi model with a good r value. The tablets were then subjected to accelerated stability studies for 3 months.

Nirmal J et al., studied the formulation and evaluation of bilayer tablets of atorvastatin calcium and nicotinic acid. Atorvastatin calcium was formulated as immediate release layer using croscaramellose sodium as superdisintegrant. Nicotinic acid was formulated as sustained release layer using HPMC K100M in varying concentration.

Remya P.N et al., studied the formulation and evaluation of bilayer tablets of ibuprofen and methocarbamol. Wet granulation technique was employed for preparing granules using PVP K 30 as binder. The bilayer tablets were film coated using Advantia prime clear film coat material. Nine batches of bilayer tablets were prepared. The Invitro release of the bilayer tablets were compared with the innovator and the release kinetics of formulation 8 was taken as optimized formular due to its higher dissolution rate and compiled all other parameters with the official specifications.

Jadhav R.T et al., formulation and evaluation of bilayer tablets of Piracetam and vinpocetine. Wet granulation technique was employed for formulation of both layers. PVP K 30 was used as binder for preparing piracetam granules and maize starch was used as binder for preparing vinpocetine granules. Sodium starch glycolate was used as superdisintegrant. Bilayer tablets were optimized based on the disintegration time and comparison of the dissolution profile with the innovator product.

Hiremath JG et al., studied the preparation and physicochemical characterization of Simvastatin loaded Mucoadhesive bilayer tablets. Tablets were prepared by direct compression technique by using mucoadhesive polymers such as carbapol, HPMC and PVP in varying concentrations. Ethyl cellulose was used as backing membrane layer because of its water impermeable nature. The core layer was composed of drug and polymer in varying concentrations. To the backing layer carbapol 934 and PVP K32 was added to avoid premature cracking. FTIR and DSC were done to study the compatibility of the drug and excipients. F3 and F9 formulations were selected as optimized batch. F3 was selected for Invitro permeation studies based on its maximum drug release F9 formulation was selected based on the Invitro drug release, swelling index and good bioadhesive strength. The optimized batches were subjected to drug release kinetics.

Ajit S kulkarni et al., prepared the floating bilayer tablets of Diltiazem hydrochloride and Lovastatin. Direct compression technique was employed for preparing bilayer tablets. Lovastatin was formulated as immediate release layer using sodium starch glycolate as super disintegrant and diltiazem hydrochloride was formulated as sustained release layer comprising of HPMC K4M and Xanthan gum as the release retarding polymers. Sodium bicarbonate was used as a gas generating agent. All the formulations released the Lovastatin within 30 minutes. HPMC K4M and Xanthan gum sustained the release for 12 hours.

Ziyaur Rahaman et al., developed the bilayer floating tablets of Captopril using direct compression technique. The floating layer was formulated with various HPMC grades (K4M, K15M and K100M) and effervescent mixture of citric acid and sodium bicarbonate. The sustained release layer comprised of Captopril and various polymers such as HPMC K15M, PVP K30 and Carbapol 934P alone or in varying combination with the drug. Final formulation released approximately 95% of drug in 24 hours, while the floating time was 10 mins and the tablet remained floatable throughout the studies. Placebo formulation containing barium sulphate in the release layer administered to human volunteers for invivo X-ray studies showed the BFT had significantly increased the gastric residence time.

Ankarao A et al., prepared the Buccoadhesive bilayer tablets of Metoprolol tartrate. Core tablet of metoprolol tartrate was prepared by direct compression technique using HPMC K4M, SCMC and Carbapol 934 as bioadhesive polymers to impart mucoadhesion and ethyl cellulose to act as a impermeable backing layer. Six formulations containing the bioadhesive polymers were prepared. The formulation F2 and F5 were optimized and obeyed zero order release kinetics with non-ficikan diffusion.

Ankarao.A et al., studied the formulation and evaluation of Buccoadhesive Bilayer tablets of Carvedilol. Direct compression was employed for preparing core tablets using HPMC K4M, SCMC, and Carbapol-934 as bio-adhesive polymer to impart mucoadhesion. Ethyl cellulose was used as impermeable backing membrane. The formulations containing HPMC and SCMC were optimized based on the buccoadhesive property and release characteristics.

REVIEW FOR METFORMIN

Bagyalakshmi.J et al., developed a bilayer formuation containing Metformin hydrochloride and Glipizide. Metformin hydrochloride was formulated as sustained release layer using varying grades of HPMC (K4M, K15M, K100M). Glipizide was formulated as immediate release layer. Due to the poor solubility of Glipizide, Solid dispersion technique using sodium starch glycolate was employed using Kneading method to improve the solubility of glipizide. The solid dispersion system was characterised by FT-IR and in vitro dissolution studies. Both the layers were optimized separately the optimized batches were then finally compressed into bilayer tablets.

Kotta Kranthi Kumar et al., designed developed and characterized sustained release of Metformin and Gliclazide bilayer tablets. Wet granulation technique was employed using various grades of HPMC for preparing granules. Trail batch of Metformin hydrochloride containing HPMC K100M and trail batch of Gliclazide containing HPMC K15M was optimized for preparing bilayer tablets. The tablets were compared with the innovator product.

Rajendran.N.N et al., formulated and evaluated sustained release bilayer tablets of Metformin hydrochloride and Pioglitazone hydrochloride. Pioglitazone Hcl was formulated as immediate release layer by direct compression method using sodium starch glycolate and crosscaramellose sodium. Sustained release layer of Metformin hydrochloride was formulated by wet granulation technique using different viscosity grades of HPMC (K4M & K100M). The immediate release layer containing varying super disintegrants was compressed separately and they were compared with the innovator product. The formulation containing sodium starch glycolate (5%) was optimized as it matched with the burst release of the innovator product. The sustained release layer was formulated by varying the concentration of HPMC K4M and HPMC K100M. The formulated tablet was compared with the innovator. The concentration of HPMC K100M (8.82%) and HPMC K4M (4.70%) was optimized as it showed the comparable release profile with the innovator. The optimized formulations were finally compressed into bilayer tablets and were studied for drug release kinetics.

Ramesh et al., formulated and evaluated bilayer sustained release tablets of Metformin hydrochloride and Pioglitazone. Dry granulation technique was employed for formulation of immediate release layer using cross caramellose sodium in varying proportions. Sustained release layer granules were formulated by wet granulation technique using bio-adhesive polymers such as sodium carboxy methyl cellulose and various grades of HPMC (K4M & K15M). The tablets were optimized separately and the optimized batches were finally compressed into bilayer tablets. The bilayer tablets gave a bimodal release indicating the immediate release followed by sustained release. The optimized batch was subjected to release kinetics to study the release mechanism.

Durga Prasad Pattanayak and Subash C Dinda design Bilayer formulation of Metformin hydrochloride and Glimepiride. Glimepriride was formulated as immediate release layer and was optimized separately. Metformin was formulated as sustained release layer. Two different matrix formulation were developed, one matrix layer with hydrophilic swellable layer such as HPMC and another matrix layer with hydrophobic layer such as PEO. The sustained release profile of HPMC matrix system was better than PEO matrix system. Thus it was optimized and compared with the innovator product. The optimized formulations were finally compressed into bilayer tablets. The tablets were subjected to study the drug release mechanisms. The formulation exhibited zero order kinetics and followed non-fickian transport.

Yamsani Madhusudan Rao et al., studied the formulation and release characteristic of a bilayer matrix tablet containing Glimepride immediate release component and Metformin hydrochloride as sustained release component. Immediate release layer was formulated by direct compression using sodium starch glycolate as super disintegrant. Sustained release layer was formulated in 5 batches by wet granulation technique using HPMC K4M, SCMC as matrix forming polymer and PVP K30 as binder. Batch 5 containing a mixture of Hydrophilic polymers in the ratio of 7.05:26.4% released the drug in the controlled manner and thus optimized and evaluated for further studies.

Madhabhai Manordas Patel et al., Design and developed bilayer gastroretentive tablets containing Metformin hydrochloride and Glipizide for the treatment of Type II diabetes. Direct compression was employed for formulating both the layers. Metformin hydrochloride was formulated as sustained release layer using various grades of HPMC. Glipizide was formulated as immediate release layer using various superdisintegrants i.e. Cross caramellose sodium, crosspovidone and sodium starch glycolate. Sodium starch glycolate (5%) was optimized as superdisintegrant for immediate release layer based on faster disintegration time. 32 full factorial design was used to optimize sustained release formulations of Metformin hydrochloride. The ratio of polymer blend (X1) and content of gas generating agents(X2) was chosen as independent variables. Among the different grades of HPMC investigated, the viscosity of the polymer affects the drug release. From the results we can conclude that prepared bilayer tablets showed desirable release profile, good floating and sustained effect in stomach.

Saptarshi Dutta, Dr.srinivas Rao studied the formulation and evaluation of Metformin hydrochloride sustained release matrix tablets. Dry granulation technique was employed using various grades of HPMC (K4M & K100M). The formulation containing HPMC K100M alone showed release profile comparable to the marketed product for a period of 12 hours and thus it was optimized. The optimized formulations was studied for drug release kinetics which showed that the formulation release the drug by diffusion. The tablets were kept for accelerated stability studies.

Dr.K.L.Senthilkumar, R.P.Ehizilmuthu formulated developed and evaluated Metformin hydrochloride sustained release tablets. Wet granulation technique was employed for formulation of tablets by using various grades of HPMC (K4M & K100M) as release retarding polymers and PVP K30 as binder. the formulation containing 13% HPMC K100 was optimized as it fulfilled the requirements for a sustained release tablets.

Jayaprakash S et al., studied the formulation and evaluation of bilayer tablets of Metformin hydrochloride. Direct compression technique was employed for formulation of bilayer tablets using sodium starch glycolate and crosspovidone as super disintegrant for immediate release layer and HPMC K4M as release retardant polymer for sustained release layer. Formulation containing HPMC K4M, SCMC as binder for sustained release layer was optimized. Immediate release layer containing Crosspovidone and sodium starch glycolate in combination was optimized. The optimized formulation was finally compressed into bilayer tablets and its drug release mechanism was studied and was found out that it followed swelling mediated diffusion. The formulations were kept for accelerated stability studies for a period of 3 months.

Manju Nagpal et al., formulation and evaluation of Metformin Oro-dispersible tablets. Direct compression method using super disintegrant approach, effervescent approach and sublimation approach was used for formulation of tablets. Formulation prepared by effervescent approach showed improved disintegration time and dissolution profile and thus it was taken as a optimized batch.

Prameela Rani A et al., studied the formulation and evaluation of orodispersible Metformin tablets. A comparative study on Isphagula husk and Crosspovidone as superdisintegrants. Direct compression technique using superdisintegrants was used for the formulation. The batch prepared using Isphagula husk (8%) was taken as a optimized formulation as it showed rapid disintegration time, hardness and good dissolution profile.

Sunil Kumar et al., formulation and evalution of extended release Metformin tablets. Wet granulation technique was employed for the formulation of extended release tablets using HPMC K100M as polymer and stearic acid and IPA as binder agent. Seven batches of formulations were prepared. Batch 7 was taken as a optimized batch as it showed better release profile compared to other batches. The optimized batch was kept for accelerated studies for a period of 3 months.

Kamlesh J. Wadher et al., formulation and evaluation of sustained release matrix tablets of metformin hydrochloride using pH dependent and pH independent methacrylate polymers. Direct compression technique was employed for formulation of tablets using pH dependent (Eudragit L-100 and S-100) and pH independent (Eudragit RLPO and RSPO) polymer combinations. Various formulations were prepared using the polymers alone or in combination. Formulation containing Eugragit S-100 and Eudragit RLPO in the ratio of 0.3:0.7 w/w gave a sustained release pattern.

Margret Chandira et al., studied the formulation and evaluation of extended release tablets containing Metformin hydrochloride. Wet granulation technique was employed for the formulation of tablets using HPMC K100M and Carbapol 71 G in combinations. Ten batches of formulations were prepared using the above polymers. Batch 10 showed the release profile comparable with the innovator product. The optimized formulation was kept for accelerated stability studies.

Ashok Kumar A et al., formulation and evaluation of Mucoadhesive microcapsules of Metformin hydrochloride with Gum Karaya. The microcapsules were prepared with a coat of alginate and Gum karaya by employing Ionotropic Gelation process and Emulsification Ionotropic Gelation process. The microcapsules prepared by Emulsification Ionotropic Gelation process was found to be spherical and showed slow and extended release over a period of time. Drug release was diffusion controlled and followed zero- order kinetics.

Lian-Dong Hu et al., preparation and Invitro/invivo evaluation of sustained release Metformin hydrochloride pellets. Centrifugal granulation was used to prepare pellets. The influence of surface modification by talc, the effects of Eudragit_ types and ratios, as well as the correlation between in vitro release and in vivo absorption were investigated in detail. The blend was coated with Eudragit L30D-55 and Eudragit NE30D at 7% or 10% level. The coated pellets showed good release profile. the absorption site specificity of metformin hydrochloride in the intestine, three dissolution media, 0.1 M HCl, distilled water and phosphate buffer (pH 6.8) was used and the release was studied.

REVIEW FOR LOSARTAN POTASSIUM

Doddayya Hiremath et al., design and characterization of bilayer controlled release matrix tablets of Losartan potassium. Direct compression technique was employed for formulating bilayer tablet. Losartan potassium was formulated as immediate release as well as sustained release layer. Immediate release layer was formulated using Sodium starch glycolate as super disintegrant. Sustained release layer was formulated using polymers such as Xanthan gum and Gum Karaya in varying proportions. Immediate release layer containing Sodium starch glycolate (6%) was optimized. Sustained release layer containing poymer in equal proportions was optimized for final preparation of bilayer tablets. The optimized formulations were subjected to study the drug release mechanisms. The tablets showed zero order release Kinetics and Non-fickian diffusion.

Varma M.M et al., studied the formulation and evaluation of Losartan potassium matrix tablets for controlled release. Tablets were prepared by direct compression technique using Carbapol 934P and HPMC K100M as polymers.11 formulations were prepared totally and all the batches showed the release profile for a period of 24 hours.

Ramya chakrahari et al., formulation and evaluation of sustained release matrix tablets of Losartan potassium. Wet granulation technique was employed using different polymers such as HPMC, Ethyl cellulose and Xanthan gum. Nine formulations were prepared. The formulation containing HPMC was optimized as it released the drugs for a period of 10 hours. The drug followed zero order release and non-fickian transport. The optimized tablets were kept for accelerated stability studies.

Prajapati B.G and Patel K.R studied the formulation and In vitro evaluation of once daily sustained release matrix tablets of Losartan potassium. Direct compression technique was employed using polymers HPMC K4M, HPMC K200M, Eudragit RSPO. 8 batches were prepared by varying the polymer concentrations. Batch 4 contianing HPMC K4M, HPMC K200M, Eudagrit RSPO was optimized based on the release profile as it sustained the release for a period of 24 hours.

Mohanthy B.R et al., development and optimization of Losartan potassium tablets. Direct compression technique was employed using sodium starch glycolate as superdisintegrant. Totally 8 formulations were prepared. Formulation 8 was selected as optimized batch as the release profile was comparable with the innovator product. The optimized tablets were kept for accelerated stability studies.

Rajesh Gollapudi et al., formulation and Invitro evaluation of sustained release matrix tablets of Losartan potassium. Direct compression method was followed for prepaing tablets using Eudagrit RLPO, RSPO and Ethyl cellulose individually or in combination. The formulations containing Eudagrit RLPO and RSPO were optimized based on the Invitro release profile and f2 factor. Mathematical analysis of the release kinetics indicated that drug release mechanism was fickian diffusion.

Suhas M kakade et al., studied the formulation and evaluation of mouth dissolving tablets of Losartan potassium. Direct compression technique was employed for preparing tablets using super disintegrants like Polyplasdone XL 10, Crosscaramellose sodium and Explotab in different concentrations. The tablets were optimized based on the disintegration time. Polyplasdone XL 10 has faster disintegration time compared to the other two superdisintegrants.

Mohd Azharuddin et al., formulation and evaluation of controlled release matrix tablets of antihypertensive drug using natural and synthetic hydrophilic polymers. Direct compression technique was employed for preparing tablets using HPMC K4M and Xanthan gum. The polymers were used alone or in combinations for the formulation of tablets. Nine batches were prepared and the 9th batch containing the polymers in equal proportions was optimized as it sustained the release for a period of 24 hours.

Lingaraj S. Danki et al., developed and evaluated gastroretentive drug delivery system of Losartan Potassium. Wet granulation technique was used for formulating the tablets by employing polymers like HPMC K4M, HPMC K 15M, carbopol 934P and sodium alginate at different drug to polymer ratios with and without gas generating like sodium bicarbonate and citric acid. Various formulations were prepared using the polymers and gas generating agents. The formulation containing HPMC K4M as polymer and gas generating agent in the ratio of 1:1 showed shorter floating lag time, good swelling property and good release profile. The optimized formulation was subjected to further short time stability studies.

Vijaya Muthumanikandar.R et al., development and Invitro evaluation of Buccoadhesive tablets of Losartan Potassium. Wet granulation technique was employed for formulation of tablets using Carbapol 934P, HPC, sodium alginate and SCMC as bioadhesive polymer. The formulation containing carbapol and HPC in the ratio of 30%:20% was optimized based on its adequate bioadhesiveness, swelling properties and release profile. The optimized formulation was studied for drug release kinetics. The formulation followed first order release kinetics. The optimized formulation was sealed in aluminium packing and kept for accelerated stability studies for a period of 3 months.

Suman.A et al., studied the formulation and Invitro evaluation of Losartan potassium floating tablets. Effervescent technique was used for formulating granules using varying grades of HPMC(K4M, K15M & K100) and using gas generating agent.12 formulations were prepared using the varying grades of HPMC. The formulation containing HPMC K100 (12%w/w of drug) and sodium bicarbonate(9%)showed rapid floating time, higher swelling and better release profile compared to the other formulations containing HPMC K4M and HPMC K15M. the optimized formulation was subjected to release kinetics.

Reeta Rani Thakur et al., studied the formulation evaluation and optimization of mouth dissolving tablets of Losartan potassium. Direct compression technique was employed for the formulation of tablets using sodium starch glycolate as super disintegrant and sodium bicarbonate and citric acid as effervescent agents. Nearly ten formulations (A-J) was formulated and evaluated for precompression and post compression parameters and it was concluded that formulation C satisfied the criteria in all aspects and thus it was optimized.

Pavithra.T.K et al., formulated and evaluated hydrogel based oral controlled drug delivery system of antihypertensive drug. Tablets were prepared by wet granulation technique. Simplex lattice design was used to develop the matrix tablets and evaluate the relationship and influence of different content levels of HPMC, Eudragit RSPO, Eudragit RLPO and ethyl cellulose in order to achieve zero order release of drug. The combination of HPMC with Eudragit sustained the release for a period of 8 hours. The tablets were then studied for drug release kinetics.

Permender Rathee et al., studied the stability indicating UV- spectrophotometric methods for simultaneous determination of Losartan potassium and Hydrochlorthiazide in pharmaceuticals. Two new stability indicating methods have been described for simultaneous assay of Losartan potassium and Hydrochlorthaizide in bulk and tablet formulation using 0.1N Hcl as solvent. Method A is based on simultaneous equation and Method B is based on Q absorbance ratio method. Both the methods have been developed and validated. Both the methods provide good sensitivity comparable to that achieved in sophisticated techniques such as HPLC. Thus these methods can be used routinely for determination of bulk sample and tablets.

Rudy bonfilio et al., studied Losartan potassium dissolution testing for drug release evaluation pharmaceutical capsules using HPLC and UV spectrophotometry. A 24 factorial design was carried out to optimize dissolution condition and phosphate buffer pH 6.8 as dissolution medium and stirring speed of 50rpm. Spectra of Losartan potassium was built in the range of 400 to 200nm using 1cm quartz cuvettes. The maximum peak was obtained at 205nm.

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