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It is a common topic over the years on which number of studies have been conducted to reveal the effects of epigenetics and to focus on its development among organisms. It was an interesting topic because it was one way of understanding genetics and its main aspects. Epigenetics also helped researchers in topics like stem cell research, preventing aging process, cloning opportunities, agriculture, synthetic biology, conservation of species, and most of all evolution. Environment is one of the factors which has a huge effect on epigenetic changes.
Epigenetic is the study of hereditary changes in phenotype due to mechanisms other than changes in the fundamental DNA sequence take place in cell division. It is a non genetic factors are the cause of organsims's genes to express differently ( epigenetics pg. 28). According to Brona McVittie the idea of epigenetic became popular in 1942 by Corad Waddignton but epigenetic actually emerges in the literature as far back as the mid 19th century back to Aristotle; he believed in epigenesis as the growth of individual organic form from the embryonic. But as the time changed, the meaning of epigenetic changed as well. However, implementation of those changes is likely to be spontaneous and is considered either as response to environment factors or in response to particular allele. Brona also stated that changes might remain throughout cell divisions for the rest of the cell's life or for multiple generations.
Everyone have different opinions about epigenetics, according to one of the editorial " modern science defines epigenetics as meiotically and mitotically stable alteration in gene expression that are not based on DNA sequence changes and involve process that impact chromatin structureâ€¦..and genomic imprinting ( 2008, wiley Liss.)"Now some people confuse epigenetics with genetics but "The difference between genetics and epigenetics can probably be compared to the difference between writing and reading a book. Once a book is written, the text (the genes or DNA: stored information) will be the same in all the copies distributed to the interested audience. However, each individual reader of a given book may interpret the story slightly differently, with varying emotions and projections as they continue to unfold the chapters. In a very similar manner, epigenetics would allow different interpretations of a fixed template and result in different read-outs, dependent upon the variable conditions under which this template is interrogated (Epigenetics pg. 28.)"
Scientists have been studying about the molecular foundation of epigenetic. Molecular basis of epigenetic is really complex, one of the molecular foundation of epigenetic involves the alteration of the activation of specific genes, but not the essential structure of DNA. According to an article Epigenetics by MeD India, "The molecular basis of epigenetics is a complex phenomenon and involves changes in the switching 'on' and 'off' of certain genes. Even the proteins associated with the DNA may be switched on or may be silenced. The phenomena of epigenetics explain why only relevant genes are selectively expressed in differentiated cells of a multi-cellular organism while the others remain silent." This article also stated that most of the epigenetic changes in an organism occurs during mitosis, while cell is dividing and are apparent only during while an individual is alive. And these changes only get inherited by the next generation only if a mutation occurs in DNA.
According to MeD India, specific processes of epigenetic include bookmarking, which is known to function as an epigenetic mechanism for passing on cellular memory of the blueprint of gene appearance in a cell throughout the cell division, to its daughter cell and bookmarking is important for sustaining the phenotype in a lineage of cells. Then comes the process of imprinting, in which the information in certain genes is active only when it goes to a child through the sperm or the egg, this system of being coping gene by the paternal or maternal source of a gene copy is called genetic imprinting. Third process of epigenetic is paramutation, which is a communication between two alleles of a cerrtain locus, resulting in a genetic change of one allele that is induced by the other allele. Next process is called gene slicing, it is a process of cutting the DNA for a gene to add base pairs done chemically by restriction enzymes that act as the scissor to cut the DNA.
Another process stated by the article Epigenetics is called chromosome X-inactivation which is also known as lionization, it is a procedure by which one of the two duplicate copies of x chromosome available in female mammals is inactivated by packaging into transcriptional inactive heterochromatin. Another process discussed in the article was Effects of teratogens is very common during pregnancy for mothers that take alcohol and tobacco during their pregnancy. Exposure to some teratogens, even in little amounts, can have disturbing effects. Some teratogens are good until they build to extreme concentration stages in the mother and then their results are seen. Some teratogens are dangerous throughout a pregnancy and some are dangerous only at specific points of embryonic development.
According to Epigenetics there are certain mechanisms for epigenetics. One of the mechanisms is DNA methylation and chromatin remodeling, "the phenotype of a cell or human being is affected by which of its genes are copied, and heritable transcription states can give growth to epigenetic effects. There are many layers of regulation of gene expression. One of the in which genes gets regulated is by the processes of remodeling chromatin. Chromatin is fused of DNA and the histone proteins with which it associates. Chromatin remodeling is capable through two main mechansisms (pg 47.)" so as the author stated that there are 2 different ways for chromotin remodeling, first one is the post translational alteration of the amino acids that are the basis of histone proteins.
So if the amino acids that are in the chain are altered, the form of the histone sphere can be changed as well. Since DNA is not completely unwound during duplication. It is possible, that the modified histones can be copied into each new copy of the DNA. So by changing the shape of the histones it would make certain that a distinguished cell would stay distinguished, and will not change into a stem cell. Another way of chromatin remodeling is by adding a methyl groups to the DNA mostly at regions of DNA where a cytosine nucleotide occurs next to a guanine nucleotide in the linear linnear sequence of bases along its length to convert cytosine to mythylcytosine. Basically methylcytosine performs similar role of a regular cytosine, by coupling up with a guanine. However, some regions of genome are methylated more deeply than others and highly methylated areas lean to be less transcriptionally active.
According to Epigenetics another mechanisms of epigenetics is RNA transcripts and encoding the proteins. "occasionally a gene, once its turned on, transcribes a product that basically maintains the activity of that gene ( pg.48)." as the author explains that RNA signaling includes differential conscription of a hierarchy of generic chromatin modifying composites and DNA methyltransferases to certain loci by RNAs while differentiation and development process. Other epigenetic changes are intermediate by the production of different splice forms of RNA, or by formatting a double-stranded RNA. Offspring of the cell in which the gene turned on will take over this activity, even if the original stimulus for gene activation is not available anymore. These genes are most probably turned off or on by signal transduction, although in some systems require gap junctions.
Another mechanism according to the book Epigenetic is fungal prions. Basically prions are proteins that folds into isolated units which perform different cellular functions, but the proteins that can form an infectious conformational state is called prions. However "Fungal prions are recognized as epigenetic because the infectious phenotype cause by the prion can be hereditary without making any change in the genome. Prions can have a phenotypic effect by the sequestration of protein in total, thereby lowering that protein's activity which results in suppression of nonsense mutations in other genes. (pg. 49.)"
According to Halyley Mann Prions are classified as epigenetic controller because they are able to change gene expression through the process of protein interactions, unlike waiting for the instruction sent by nucleic acid. As with viral and bacterial pathogens, prions have ability to replicate themselves without any involvement or instruction sent by nucleic acids. Prions instead of converting into native forms, it turns it into more prions. Furthermore, prions come in special strains and reveal differential specie host preferences. Then during prion pathogenesis, the initial appearance of the protein is changed to the insoluble amyloid conformation. These amyloids make collection of fibrous proteins which eventually direct to amyloidosis and which turn into taxic neurodegenerative symptoms. So basically there are many mechanism of epigenetic.
According to the book Epigenetics certain environmental and dietry factors are the cause to abnormal changes in epigenetic pathways. One of the environmental factor discussed in this book was usage of heavy metals. Heavy metals like camium can disturb DNA methylation which of course is an important part of normal organsimal development and cellular differntation in higher organisms. Then comes the next factor, which is the wide use of pesticide. One of the examples of using pesticide is using vinclozoling, it is a pesticide that can alter DNA methylation with its exposure.
These changes persist in unexposed offspring through several generations.
Then comes the most important one which mostly people ignore is smoking tobacco, "maternal cigarette smoking during pregnancy is related with poor fetal outcome and abnormal miRNA expression is related with unfavorable pregnancy outcomes and variations in brain and behavior in adolescence. Epigenetic mechanisms may mediate some of the consequences of PEMCS through methylation of deoxyribonucleic acid in genes important for brain development, such as the brain-derived neurotrophic factor (pg. 64)." And according to one of the study done in the book Epigenetic states that compared with never smokers, women who first started to smoke during follow-up had an increased risk of acquiring methylation of p16. It also reveals, for the first time, that the relationship between starting to smoke and the subsequent appearance of an epigenetic change."
Also according to Med India's article Molecular basis of epigenetics The link between smoking and cancer has been established for decades. Smoking is the single biggest cause of cancer in the world, and years of research have confirmed that carcinogenic substances in tobacco smoke can damage DNA. Also exposure to tobacco is a major component during early development relics a common but stoppable toxic exposure, which has been clearly related to decreased lung growth and later asthma illness. There is a rising evidence that tobacco smoke can influence early immune function. Although parental smoking may not be the primary factor in the changing occurrence of asthma and respiratory disease, research suggest that it is an important provider, with significant ability to communicate with other genetic factors and environmental risk factors to manipulate disease tendency. It shows the aspects and the results of smoking during early development, including potential mechanisms, interactions with influencing asthma genes and a potential role in epigenetic regulation.
According to the book Epigenetics cancer is a muti step procedure in which genetic and epigenetic mistakes gather up and change a normal cell into an persistent or metastatic tumour cell. Epigenetic changes have been observed in virtually every step of tumor development and progression. Too little DNA methylation which is also known as hypomethylation is believed to initiate chromosome unsteadiness and activate oncogenes. On the other hand, too much DNA methylation which is known as hypermethylation may initiate the silencing of tumor suppressor genes. Additionally, mutations early in the origin of common cancers have also been identified and these are likely to be related with tumor instigation. In contrast, few certain genetic mutations have been associated to tumor progression, resulting to the suggestion that epigenetic changes may be involved. Epigenetic changes happen without a change in the DNA sequence and they can be stimulated by various factors. Thus it is likely to occur, for example, that a DNA mutation direct to cellular transformation, but stimulate changes in the epigenome of the altered cell develop the possibility that it will be competent of metastasising In this situation, a genetic mutation begins the cancer but epigenetic change supports its growth and further development.
Epigenetic processes may also be involved in cancer initiation. It is possible that epigenetic change may lead directly to cancer initiation Alternatively, changes already encourage within the epigenome may make a copy of cells in such a way as to promote cellular transformation upon a subsequent DNA mutagenic event. In this case the epigenetic component of the cancer initiation is related with the genetic component. The involvement of epigenetic change in cancer initiation is of course not mutually exclusive to it having also a role in cancer development.
According to Bob Weinhold "Both increases and decreases in DNA methylation are associated with the aging process, and evidence is accumulating that age dependent methylation changes are involved in the development of neurologic disorders, autoimmunity and cancer in elderly people. Methylation changes that occur in an age related manner may include the inactivation of cancer related genes. In some tissues, levels of methylated cytosines decrease in aging cells, and this demethylation may promote chromosomal instability and rearrangements, which increases the risk of neoplasia which is the abnormal proliferation of cells.In other tissues, such as the intestinal crypts, increased global hypermethylation may be the influence event that accounts for the increased risk of colon cancer with advancing age." So basically It has been shown that the process of aging involves some epigenetic pathways that have been identified in the process of carcinogenesis which is basically a creator of cancer.
Bob Weinhold also states that the activation of the immune response engages a lot of steps to lead to epigenetic changes, which allow individual cells to grow a specific immune response that can be sustain and survive over multiple generations of a cell.
Also the role of epigenetic errors in the development of complex adult psychiatric, autistic and neurodegenerative disorders. David and Melissa stated that related schizophrenia and mood disorders with DNA rearrangements that include the DNMT genes. whereas hypermethylation has been shown to repress expression of Reelin which is a protein required for normal neurotransmission, memory formation and synaptic plasticity in brain tissue from patients with schizophrenia and patients with bipolar illness and psychosis.
According to the book Epigenetics, epigenetic in multicellular organisms is normally thought to be a process related with differentiation, while epigenetic patterns reset when organisms reproduce, there have been some observations of trans-generational epigenetic inheritance Although most of these multi-generational epigenetic traits are gradually lost over many generations, the possibility remains that multi-generational epigenetic could be another feature to evolution and adaptation. Epigenetics helps to understand how enormous variations originated and evolved into present days life. Alterations in series of DNA level such as addition, deletion, reshuffling of sequences and rearrangement of chromosomes are major tools for creating variation upon which natural selection acts. Besides these, mutation also does its role in evolution by creating genetic alteration in chromosomes.
In conclusion, the role of epigenetic and environment plays a great role in development and evolution, because as David stated that "It has profound implications in aging, neurological disorders, and child development. Epigenetics could prove more important than genetics for understanding environmental causes of disease. Cancer, atherosclerosis, Alzheimer's disease are all acquired diseases where the environment very likely plays an important role, And there's much more potential for the epigenome to be affected â€¦ than the genome itself." NEEDS THE CLOSING LINE: CONSUT AQSA