Revised Submission Of Manuscript For Publication After Corrections Biology Essay

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We, hereby, are submitting a revised manuscript titled 'Efficacy of Hayman Suture Technique in the Management of Atonic Post-Partum Hemorrhage' for publication in your esteemed journal under 'original article'. The itemized response to reviewer's comments has also been attached herewith.

On behalf of all the authors I, Dr. Anamika Majumdar, will be the corresponding author.We assure that the contents of the manuscript have not been already published and the paper is not being submitted elsewhere. There is no potential conflict of interest and prior publications.

All authors have contributed significantly in each stage of conceive and planning of the work; as well as, writing, review and revision of the paper. I, Dr. Anamika Majumdar, the first author of the study, am hereby accepting the responsibility for ensuring that the version of the paper submitted has approval of all the coauthors. The future corrected proofs will also have approval of all authors.

Thanking you,

Yours sincerely,

Dr. Anamika Majumdar,

Assistant Professor, Department of Obstetrics and Gynecology,

Surat Municipal Institute of Medical Education and Research (SMIMER), Surat

Itemized response to reviewer's comments

Comment 1: Why the study was carried out is not well justified in the introduction

Response 1: Aim of study has been detailed in the last para of introduction

Comment 2: How the patients were followed up is not given although conclusions include long term efficacy

Response 2: Follow-up table is included

Comment 3: Conclusions are not justified by the result eg: easily and rapidly applied

                      fertility preserving etc. but authors have concluded as such

Response 3: The above said concluding sentence have been removed

Comment 4: Results section include some methodological statements and has to be re arranged.

Response 4: The method part in result section is removed

Comment 5: Retrospective study of this nature is limited by inability to varify the blood loss pre and post procedure which has to be acknowledged by the authors in conclusion

Response 5: The limitation included in conclusion

Title page

Title of manuscript:

Efficacy of Hayman Suture Technique in the Management of Atonic Post-Partum Hemorrhage

Authors in order with affiliation:

Anamika Majumdar1, Kallol Mallick2, Bipin Vasava2, Kanan T. Desai3, Malati Dalal4

1 MD, Assistant Professor, Department of Obstetrics and Gynecology, Surat Municipal Institute of Medical Education and Research (SMIMER), Surat

2 MD, Assistant Professor, Department of Community Medicine, Surat Municipal Institute of Medical Education and Research (SMIMER), Surat.

3 MBBS, Postgraduate resident, Department of Community Medicine, Surat Municipal Institute of Medical Education and Research (SMIMER), Surat.

4 MD, Professor & Head, Department of Obstetrics and Gynecology, Surat Municipal Institute of Medical Education and Research (SMIMER), Surat

Institute of study:

Surat Municipal Institute of Medical Education and Research (SMIMER), Surat.

Financial support:


Corresponding author:

Dr. Anamika Majumdar,

Assistant professor, Dept of Obstetrics and Gynecology,

Surat Municipal Institute of Medical Education and Research (SMIMER),

Opp. Bombay market, Umarwada,


Contact no.: 09426772605

E-mail address:

Running title:

Haymen Suture in Post Partum Hemorrhage




To study the effectiveness of Hayman suture technique to control postpartum hemorrhage. Method:

Hayman suture was applied in 43 cases. A No-1 Vicryl suture was used on a round body or a straight needle. In 36 cases (83.72%) Hayman suture was the only intervention. In 4 cases (9.30%) uterine vessels and ovarian vessels were also ligated along with Hayman suture. In 3 cases (7%), along with Hayman suture, Gunasheila's circumferential sutures were taken. Results:

None of the 43 patients required hysterectomy.


Hayman suture technique is an easily and rapidly applied, effective, simple, safe, life saving and fertility preserving method to control atonic postpartum hemorrhage.



Atonic Post Partum Hemorrhage, Hayman Suture, B-Lynch Suture.



It has been estimated that world wide over 125000 women die of postpartum hemorrhage (PPH) each year1. PPH complicates approximately 3.7% of vaginal and 6.4% of caesarean delivery2. In India 25.6% of maternal deaths are due to hemorrhage3. Uterine atony accounts for 75%-90% of primary PPH. The traditional management of this condition begins with conservative methods such as bimanual compression, medical therapy with uterotonic agents, uterine temponade with balloons and occasionally arterial embolisation4, the failure of which often mandates surgical intervention. Surgical measures such as ligation of the major pelvic vessels demand a rarely used skill possessed by few registrars. In the event of intractable hemorrhage, despite the above measures, hysterectomy is usually the final resort.

In 1997, Christopher B- Lynch devised an innovative technique to treat uterine atony, where a continuous suture was used to envelop and mechanically compress the uterus in an attempt to avoid hystrectomy4. Hayman suture, the modification of B- Lynch suture, offers the potential advantage that it can be applied faster and easier, avoiding the performance of a lower segment hysterectomy when PPH follows a vaginal delivery5.

The aim of our study is to review the cases in which Atonic PPH was not controlled with the available drugs (uterotonics), where fertility preserving Haymans sutures were applied over highly skillful obstetric hysterectomy in our institution and their clinical outcomes.

Materials and methods

A retrospective study of all women who delivered between April, 2007 and March, 2010 was collected from our departmental database. Primary PPH is defined as a blood loss of more than 500 ml at or with in 24 hours of delivery. There were a total of 18,750 deliveries during this period, with primary PPH occurring in 938 of these cases. The Hayman suture procedure was performed in 43 cases only after uterine atony did not respond to measures such as uterine massage, bimanual compression and the use of uterotonics, i.e. Oxytocin, Ergometrine, PG-F2α, Misoprostol. Out of these 43 cases, 38 cases delivered in our institute and 5 cases were referred from other hospital. The need for hysterectomy was avoided in all the cases. Uterine and ovarian vessel ligation was done in 4 cases and Gunashila's universal circumferential sutures were taken in 3 cases in addition to Hayman suture. The procedure was done with Vicryl No-1 (Polyglactin) in all the cases.

The procedure for Hayman suture technique was as follows:

The patient was given appropriate anesthesia and catheterized.

The abdomen was opened by an appropriate sized incision or if the patient had a caesarean section, the same incision.

On entering the abdomen the uterus was exteriorized and rechecked to identify any bleeding point. If bleeding was diffuse as in uterine atony, coagulopathy, or profuse placental bed bleeding where no obvious bleeding point is observed, then bimanual compression was first applied to assess the potential chances of success of the Hayman suturing technique. The vagina was swabbed to confirm adequate control of the bleeding.

If the vaginal bleeding was controlled, a straight needle or a curved needle is used to transfix the uterus from front to back, just above the reflection of the bladder and is then tied at the fundus of the uterus. This can be done as one suture on each side of the uterus or more than one suture if uterus is particularly broad6.


Age distribution of women is shown in figure 1, majority of the patients were in the age group of 20-25yrs. Gestational weeks of women in table 1, most of the pregnancy were term pregnancy. Mode of delivery of women is as in figure 2, out of 43 patients 34 delivered by LSCS. Type of intervention is as given in table 2. In 36 patients, hayman sutures alone were taken. In rest of the 7 patients additional methods like ligating uterine Artery and ovarian Artery( in 4 patients) and Gunasheilla's universal sutures were taken( in 3 patients). Numbers of primary cases is given in figure 3, 9 patients were referred from outside. Follow up of the patients was as per table 3, out of the 43 patients, 14 became pregnant of which 5 delivered subsequently.

Figure 4 shows the photograph of Hayman suture taken in a case of atonic PPH.

All the cases had evidence of uterine atony which responded poorly to conventional uterotonics. Bleeding was controlled in all the cases with Hayman sutures thus averting hysterectomy. Also, the entire patient's had an uneventful post-operative recovery except in one referred case, in whom bleeding was controlled with Hayman sutures but later she developed septicemia plus Acute Respiratory Distress Syndrome (ARDS) and died on 21st postpartum day.


Christopher B-Lynch's original case series of five patients underwent the B-Lynch's procedure for massive PPH as conventional uterotonic agents proved ineffective4. In 2002, Hayman placed two vertical sutures on each side of the fundus of the uterus in three patients with PPH without performing a hysterotomy7. The procedure was successful in preserving the uterus and hence fertility. Although uterine atony is often the indication for the use of the compression sutures, it has been shown in many case reports that the suture is also useful in controlling bleeding in cases of placenta previa and placenta accrete.7

Various suture materials have been tried, including Vicryl (polyglactin910), Dexon (polyglycolic acid), PDS (polydioxanone), prolene (monofilament polypropylene) and nylon. It is believed that the ideal suture should be strong, monofilament (to minimize possible trauma to the friable tissue of the atonic uterus), quickly absorbed, and mounted on a large curved or on a straight needle. Ideally the suture needs to maintain the tensile strength for 48-72 hours. In our series of 43 cases, Vicryl was used in all, although this was not recommended for the reasons stated above, there were no subsequent long term complications encountered in these patients.

There have been isolated reports of adverse consequences after B-Lynch application. In 2004, Grotegut et al reported one case of erosion of a B-Lynch suture through the uterine wall, in a 19 year old primigravida8. Partial ischemic necrosis of the uterus occurring 24 hours after the procedure has also been reported in a 26 year old primigravida, who underwent an emergency caesarean section for fetal distress followed by B-Lynch suture 9.The effect of the erosion on future fertility and labor remains unknown. Despite this, many patients on long term follow up have demonstrated resumption of normal menstrual periods and normal reproductive health10.

Long term complications such as, formation of bowel adhesion have also been reported 7.

Comparing B-Lynch suture with Hayman suture, B-Lynch is time consuming and there is bleeding from uterus due to multiple bites. Uterine opening is avoided with Hayman suture. Cervical stenosis, haematometra, partial necrosis and sloughing of uterine wall have been documented by various surgeons as a complication of original B-Lynch suture technique. Since modified B-Lynch brace sutures is a newer technique, and most of the studies are based on case reports and are without proper controlled studies, more controlled studies are required before it is accepted as a standard method 6.

In our series, none of the patients had any known adverse outcome till date. Our series of 43 patients illustrate the usefulness of the Hayman procedure in the management of intractable PPH, thus avoiding hysterectomy. To date, we have no further data of continued fertility in patients whose uterus was preserved. There is no randomized controlled data comparing Hayman procedure to other methods of haemostasis for PPH, and it is unlikely that such data would ever be forthcoming, given that PPH is often unanticipated and occurs under urgent or life threatening situations, thereby rendering randomization and the process of controlling for variables extremely is difficult, if not impossible to implement and ethically questionable 10.

Conclusion: Our initial series of cases of atonic PPH treated with Hayman procedure shows that it is an effective method of controlling PPH. The Hayman suture has the advantage of being applied easily and rapidly. It should be attempted as early as possible in order to maximize its success and prophylactic application should be considered in patients at high risk. Application of a Hayman sutures should be taught to all trainees and registrars in obstetrics. Its relative simplicity and ease of application, its life saving potential, relative safety, and above all, its capacity for preserving the uterus, makes it the recommended procedure of choice if conservative measures do not control PPH, and should be attempted before any radical surgery is considered. It does not require any extra skill and even a resident doctor or a junior doctor can perform it.

Limitation of study:

Retrospective study of this nature is unable to verify the blood loss pre and post procedure.