Overview Of Generic Actos Biology Essay


Actos (Pioglitazone) is an oral medicine to treat only type 2 diabetes. At times the doctor may prescribe Actos along with a combination of insulin if required. Generic Actos is not available in the USA as of now. Actos is currently manufactured by Takeda Pharmaceutical Company which holds the patent for the drug. Generic Actos can be manufactured by any other pharmaceutical company other than the original manufacturer only after the patent expires. The first patent would expire in 2011. But there are other patents which would protect the drug from the generic version till August 2012. So the earliest that Generic Actos will be available in the American market is 17th August 2012.

Generic Actos is a prescription drug used to treat type 2 diabetes. It belongs to a class of medicines known as thiazolidinediones. Generic Actos may be available in countries outside the USA. Many online pharmaceutical companies sell Generic Actos even without a prescription and that too at cheaper rates. A patient is warned against purchasing these drugs as they may not be genuine.

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The active ingredient in the medicine Actos is Pioglitazone. But many people refer to this active ingredient in the drug as generic Actos. The generic name of the drug is however different from the generic version of the drug.

Before taking Actos, a patient must talk to his or her doctor and understand the contra indications and the problems a person can encounter while taking the drug. Patients who are allergic to Pioglitazone, those who have suffered a heart failure and liver problems should avoid Actos. Actos can also lead to hypoglycemia. Patients should learn to recognize its symptoms which are headache, weakness, hunger, sweating and tremors to name just a few. Therefore it is wise to always carry a sweet or candy bar to prevent hypoglycemia.

Actos should be taken according to the doctor's prescription and if a dose is missed the patient should guard against overdosing himself by taking a double dose of the drug. Women who take Actos can suffer broken bones especially of the hand, foot and the upper arm as bones tend to become brittle.

Generic Avandia

Avandia, a prescription drug, is manufactured by the renowned pharmaceutical company Glaxo Smith Kline. As Avandia is currently protected by a patent, Generic Avandia will not be available in the USA till the patent expires in 2012. It may be available outside the USA but it is not clear how genuine these medicines are. Once Avandia goes off patent, then pharmaceutical companies other than Glaxo Smith Kline can manufacture Generic Avandia.

Avandia (Rosiglitazone) is available in dosage strengths of 2, 4 and 8 mg and is ideal for treatment of patients suffering from type 2 diabetes since it belongs to a class of drugs known as thiazolidinediones. Insulin, the hormone which controls blood sugar levels in the body is produced by the pancreas. It also stimulates the cells in the body to eliminate glucose thus lowering blood sugar levels. But a patient who suffers from type 2 diabetes cannot produce sufficient insulin in his body or can also be resistant to insulin. So, the cells in a patient's body cannot remove the glucose from the blood thus leading to a rise in the levels of blood sugar in the body. Avandia being an "insulin sensitizer" attaches to the insulin receptors of the cells, thus causing the cells to be more sensitive to insulin and lowering blood sugar levels.

As Avandia is known to enhance the probability of heart attacks and strokes, its usage has been severely restricted by the FDA in September this year due to which its usage is limited only to type 2 diabetic patients since they cannot rely on other medicines for controlling their blood sugar levels. Side effects of Avandia include upper respiratory tract infection, back ache, head ache, both hyperglycemia and hypoglycemia, and fatigue. Pregnant women and nursing mothers should tell the doctor before starting Avandia.

If one searches the internet, it is possible to come across many pharmaceutical companies selling Generic Avandia. But these drugs could be fake, sub standard and even dangerous.

Generic Januvia

Januvia (Sitagliptin) is a prescription drug which is used to treat patients afflicted with type 2 diabetes which is also referred to as non- insulin dependent diabetes or adult-onset diabetes. This drug can be used either as a single medicine or in combination with other diabetes medicines. Januvia is currently being manufactured by Merck and Company Inc. Januvia is protected by a patent and so Generic Januvia is not available in the markets in the USA now.

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Once Januvia goes off patent, then other pharmaceutical companies can start manufacturing Generic Januvia. But this will not happen till 2017 when the first patent on Januvia expires. The active ingredient of the drug Januvia is Sitagliptin. Often people consider the active ingredient as the generic name of the drug, not knowing that the generic name and the generic version of the drug are two different things.

Januvia is an oral diabetes drug which helps to control the blood sugar levels. It regulates the insulin produced in the body after eating a meal. Januvia is a dipeptidyl peptidase-4 inhibitor, (DPP-4). It acts by increasing the amount of insulin produced in the body and also decreases the quantity of sugar made by the body. Patients who are allergic to Sitagliptin or who suffer from diabetes ketoacidosis, kidney or liver diseases, and pancreatitis should not take Januvia.

Side effects of Januvia include severe pain in the region of the upper stomach which radiates towards the back, nausea and vomiting, loss of appetite and a fast heart rate. In case of any of these symptoms the patient should see a doctor immediately. A patient who is taking Januvia should take care not to skip any meal as it would lead to hypoglycemia. Head ache, tremors, weakness sweating and hunger are some of the signs of hypoglycemia that a patient should look out for. Many pharmaceutical companies claim to sell generic Januvia on line. But these medicines may not be genuine and could be dangerous.

Generic Starlix

Starlix is a prescription drug which was first manufactured by Novartis. Now that Starlix is off patent, Generic Starlix is available for sale in the USA. It is a prescription drug meant for patients suffering from type 2 diabetes since it belongs to a class of drugs known as meglitinides. Generic Starlix works by helping the pancreas to produce more insulin and lower blood sugar levels in the body especially after a meal.

Generic Starlix is sold as Nateglinide by different pharmaceutical companies. The companies that manufacture and sell Generic Starlix are Dr. Reddy's laboratories, Teva Pharmaceuticals and Par Pharmaceuticals. The drug is available in two different dosage strengths of 60 mg and 120 mg.

Generic medicines have to undergo certain tests which compare them to their brand - name medicines. These tests are checked out by the US food and Drug Administration which then decides whether the generic versions of the drug are as good or can be compared with their branded medications. The FDA then assigns a rating to the generic versions of the drug. Generic Starlix has a FDA rating "AB" which means that it is as good or is equivalent to its brand -name medication.

Generic medicines have many different inactive ingredients like fillers and dyes. These inactive ingredients can sometimes cause allergies in people who are sensitive and hence patients must be careful while taking generic drugs.

For best results, a type 2 diabetic patient should be careful about his diet and also be regular with his exercise while taking generic Starlix. Generic Starlix is contraindicated if the patient is suffering from diabetic ketoacidosis, liver disease, is allergic to Nateglinide, food dyes or preservatives. Pregnant women and nursing mothers should take the doctor's advice before taking generic Starlix. This drug reacts adversely with medicines like aspirins, anabolic steroids, medicines for asthma and weight loss medicines.

Generic Janumet

Janumet is a prescription drug which is manufactured by the pharmaceutical company Merck and Company Inc. Generic Janumet is currently unavailable in the USA as the drug Janumet is under the protection of a patent. The earliest one can expect Generic Janumet to be available in the US markets is in 2019 when the first patent expires and pharmaceutical companies other than Merck and Company Inc will start manufacturing Generic Janumet.

Janumet has two active ingredients Sitagliptin and Metformin. As such, it is a combination drug to treat type 2 diabetes. Janumet contains Januvia (Sitagliptin) and Metformin (medicines like Fortamet Glucophage, Riomet). This drug acts in two ways. Sitagliptin regulates the insulin levels produced in the body after eating, while Metformin decreases or lowers the production of sugar in the liver and also reduces the absorption of glucose by the intestines.

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The drug Janumet is contraindicated in the following cases.

In case a patient suffers from any liver or kidney disease.

If a patient is allergic to either Sitagliptin or Metformin.

If a patient suffers from diabetic ketoacidosis.

If a patient suffers from pancreatitis.

In case a patient has to take a CT scan or an X-ray where a dye has to be injected into the veins, then Janumet should be stopped temporarily.

The general side effects of Janumet are acidity (gas), nausea, stomach upset, headaches and when the drug is combined with another diabetes medicine rosiglitazone, it leads to swelling of feet and hands. A rare but serious side effect is lactic acidosis, which is more likely to affect a diabetic patient who has a kidney or liver disease, or a severe infection. In case of any of the above mentioned side effects, the patient should see his doctor at once. In case of pregnant women and nursing mothers, it is better to take the doctor's advice before taking Janumet. If one searches the net it is possible that many companies would sell Generic Janumet at discounted prices. But these medicines may be fake and dangerous so it is better to avoid them.