Neurobrucellosis Report Of One Case With Cva Manifestation Biology Essay


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A 42-year-old man was admitted with an episode of faint without loss of consciousness, right hemi paresis, diplopia and headache that were lasting 4 days. The neurological examination revealed left hemi paresis. Limitation of gazing in left eye in lateral view was seen (partial paresis of 6th cranial nerve).

The results of laboratory examinations show positive Wright and Coombs Wright in blood and C.S.F. In the brain CT scan hydrocephaly and in magnetic resonance imaging (MRI) some brain atrophy, few high signal foci in the deep with mater been detected.

Treatment included concurrent administration of three of the following drugs: doxycycline, rifampicin, co-trimoxazole. This patient fully recovered.

We suggest that NB should always be sought in young patients with ischemic stroke, especially if they do not have any additional risk factors for stroke and live in an endemic area for brucellosis, even if they do not have other systemic signs of brucellosis.

Keywords: brucellosis, ischemic stroke


Brucellosis, a zoonosis disease that affects animals as the primary host (eg, camels, sheep and goats) and humans as the secondary host,1 is still a common health problem in some Middle Eastern and Mediterranean countries.1-4 Nervous system involvement occurs approximately in 2-10% of the patients infected with brucella.1-7 Neurobrucellosis (NB) may develop at any stage in the evolution of the disease and may involve several areas of the central and peripheral nervous system. Therefore, NB has widely variable manifestations, including meningoencephalitis, myelitis, radiculitis, neuritis, spinal cord compression and demyelinative or vascular diseases of the central nervous system (CNS), or any combination of these disorders.4-8

The most typical presentation of CNS involvement in brucellosis is chronic meningoencephalitis with mononuclear pleocytosis, decreased glucose and increased protein concentrations in the cerebrospinal fluid (CSF).7 Uncommon clinical presentations of NB such as migraine, Parkinsonism, optic neuritis, chronic intracranial hypertension, and epilepsy have been reported.4,8-11 Brucellar meningitis may also behave as an exclusively neurological disease mimicking vascular accidents that are frequently paroxysmal and recurrent.1,2,4 Here we report one case with brucellosis as an exceptional cause of C.V.A.

Case Report:

A 42-year-old man was admitted with an episode of faint without loss of consciousness, right hemi paresis, diplopia and headache that were lasting 4 days. The patient had also shoulder and neck pain and anorexia from last 2 months. He had not HTN, diabetes and others chronic diseases. This patient was farmer.

In general physical examination fever (38.7 C) detected. Blood pressure was 110/70 mmHg and pulse 86/min. Examination of heart and lungs were normal. The neurological examination revealed right hemi paresis and upward plantar reflex on the left side. Limitation of gazing in left eye in lateral view was seen (partial paresis of 6th and 7th left side cranial nerves). The patient was evaluated for stroke in young adults.

Results of laboratory examinations shown in Table 1. In blood sample was seen leucocytosis (85% neut), positive Wright and Coombs Wright. C.S.F was Wright positive. The platelet count, BUN, Cr, Cholesterol, T.G, Uric Acid, Na, K, PTT, PT, U/A, vasculitis tests and echocardiography were normal.

In the primary brain CT no lesion seen but some days later hydrocephaly been detected. In brain magnetic resonance imaging (MRI), some brain atrophy and few high signal foci in the deep white matters of both brain hemisphere was reported. There was not any S.O.L in the supra and infra tentorial structures.


Brucellosis, although almost eradicated in many parts of the world, still remains widespread and endemic in the developing countries.3,4,7 Neurological involvement during the course of brucellosis occurs in about 2-10% of the cases.5,6,13 Clinical diagnosis of NB can be very difficult because of various presentations. Several clinical forms of brucellosis affecting the CNS have been reported including meningitis, meningoencephalitis, myelitis, myelopathy and demyelinative or vascular diseases of the CNS.2, 3, 4, 5, 7

Our patient presented with an episode of neurological deficit that was compatible with right hemi paresis and dysfunction of 6th and 7th left side cranial nerves.

The endemic occurrence of brucellosis in Kurdistan, positive serology in serum and CSF for brucellosis, exclusion of other vascular diseases and causes of ischemic cerebral symptoms, and good response to treatment with antibiotics led to the diagnosis of NB. A similar clinical presentation of NB was also reported by other authors and defined as transient brief attacks or intermittent cerebral vascular insufficiency. 3,4,7,14

Bingol reported four case with transient ischemic attacks (TIA) or ischemic stroke as the predominant manifestation of neurobrucellosis. In one patient transient brief attacks followed by a ruptured basilar artery aneurysm and in another one accompanied by xanthochromia.4 But as in ours, most of the patients with ischemic cerebral symptoms in Bingol reporte and other report have normal cerebral angiograms.4, 13

Al-Deeb has reported a man who presented with dysarthria and left hemiplegia of acute onset and his CT showed a frontoparietal infarct, but cerebral DSA was normal. The authors proposed that normal appearance of cerebral vessels in DSA was consistent with vasculitis of deep penetrating arteries.7 Three types of imaging abnormalities can be seen in neurobrucellosis: inflammation, white matter changes, and vascular insult. Inflammation may cause granulomatous formation or enhancement of the meninges, perivascular space, or lumbar nerve roots.1

As a manifestation of basal meningeal infection, involvement of one or more cranial nerves has been noted in more than 50% of the cases.13 The vestibulocochlear nerve has been described as the most frequently involved cranial nerve in NB. Its involvement is usually combined with other neurological dysfunctions.3,4,15 Neurobrucellosis may develop at the onset of the illness, during convalescence or months to years after recovery from the acute systemic infection.4

The pathogenesis of TIA and ischemic stroke in brucellosis still remains uncertain. It has been proposed that TIA in brucellosis may be related to infectious vasculitis, cerebral vasospasm or cardioembolism.7,14 Various degrees of vascular inflammation ranging from acute to chronic with the possibility of necrosis and aneurysmal formation has been described in CNS brucellosis.4

The final diagnosis of NB was made on the basis of the serological tests or culture for brucella in CSF. Other criteria supporting our diagnosis were: a history of consumption of unpasteurized milk or milk products, systemic complaints of brucellosis, such as headache, malaise, weight loss, anorexia, dorsal pain and nausea-vomiting, progressive bilateral sensorineural hearing loss without any other cause, C.V.A not associated with other well-known risk factors of ischemic stroke, lymphocytic pleocytosis in CSF with increased level of protein, and decreased level of glucose.

In chronic NB, increased IgG index and/or oligoclonal banding pattern in CSF electrophoresis can be detected as in many other chronic inflammatory processes of the CNS.4,16 Normal levels of IgM in serum and CSF also indicated that the infection was in the chronic stage.

Trimethoprim/sulfamethoxazole, rifampicin and doxycycline which have good intracellular and CNS penetration and which are synergistic are the most commonly used antibiotics to treat brucellosis. Prolonged treatment (at least 6 months) with a combination of these three antibiotics was used in our patients successfully.

As Bingol8 concluded, recognition of ischemic stroke because of brucellosis and its differentiation from other vascular diseases are not easy, particularly in elderly patients with stroke risk factors such as hypertension, diabetes, atrial fibrillation, etc. We suggest that NB should always be sought in young patients with ischemic stroke, especially if they do not have any additional risk factors for stroke and live in an endemic area for brucellosis, even if they do not have other systemic signs of brucellosis.

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