Common Form Of Cancer In Caucasians Biology Essay

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This study was undertaken to analyze the all histopathological subtypes and tumor diameter with epidermal ulceration of head and neck localized BCC with regard to sex, age and anatomical distribution in a population from the Mid-Anatolian Region of Turkey.

Methods: Ninety-five patients histopathologically diagnosed with BCC of head and neck at Çankırı State Hospital was retrospectively examined and assessed. The diagnosis and subtypes with the tumor diameter and epidermal ulceration were confirmed by two pathologists. Gender, age at excision and location were recorded.

Results: The mean age at excision of a BCC was 69.98 ± 13.07 years. The nodular BCC was the most frequent type (23.2%), followed by the superficial and micronodular types (22.1%). The micronodular, nodular and superficial BCC occurred more often in males and solid and infiltrative types more often in females. Almost all types showed slight predominance for nose localization. The superficial form was the dominant type on the cheek. The mean tumor diameter is 8.94 mm with the range of 0.5-38 mm. There was a statistically significant difference between the micronodular with the smaller diameter of 5.25 mm and the other types of BCC diameter. Epidermal ulceration was observed in most of the patients (77.9%) and there was not any significant difference among the types of BCC.

Conclusions: Our results confirmed the outcomes of the previous reports in the literature. We found that the superficial type of BCC of the head and neck region most commonly occurred on the cheek.

Key words: Head and neck, basal cell carcinoma, histopathological subtype

INTRODUCTION

Basal cell carcinoma (BCC) is the most common cancer worldwide in white-skinned populations. Incidence rates vary hugely with geographical location (1). Despite the high prevalence of this tumor, there is a lack of reliable epidemiological data in most European countries. Recent studies suggest that BCC is not a single entity. It has been hypothesized that BCC occurring at certain body sites or BCC of a particular histological subtype may define certain clinical behavior and it may even have a different etiology (1-5). Further data from these studies have shown that the histological subtype most commonly occurring on the trunk is the superficial type and that there is a trend towards an increasing proportion of all BCCs to occur on the trunk. These observations have again raised the issue of whether intermittent or cumulative sun exposure or a combination of both initiate and/or promote BCC occurring on less exposed body sites such as the trunk (2-5). In 1995, Kricker et al. had postulated an increased risk of BCC from intense 'bursts' of sun exposure that exceeded the risk of a similar exposure spread evenly over the same total period of time (6). Unfortunately, their large case-control study did not differentiate the histological subtypes of BCC. The histopathological differentiation of BCC subtypes is based on the different growth patterns, which are also the basis of the current classification system suggested by the World Health Organization (WHO) (7). This classification, which has shown practical relevance, broadly distinguishes between nodular, superficial and infiltrative BCC. In addition, micronodular BCC has been separately recognized as a high-risk subtype because of the elevated likelihood of recurrence. Other recognized subtypes of BCC as well as mixed types occur less frequently (7-9). Although BCCs rarely metastasize, costs related to the treatment of BCC are substantial in countries with a high incidence rate such as Australia, and morbidity from certain histological subtypes of BCC can be substantial due to their clinical behavior (10,11). Recurrence rates overall are higher in BCC than in squamous cell carcinoma (SCC) (12). Infiltrative and micronodular BCCs are considered high-risk histopathological subtypes because they are more likely to be incompletely excised and/or to recur especially on the face where surgical margins might be conservative (9,11,13).

Superficial BCCs have also been classified as 'high risk', because of their propensity to recur as they may be incompletely excised without necessarily showing tumor in the excision margin on histological examination (13,14). Ideally, the reporting of the histopathological subtype of the BCC together with host demographics and body-site information should relate to and enhance clinical information and ultimately improve treatment regimens (12). In addition, studies on the relationships between these factors could help to clarify the link between sun exposure and BCC (1,14,15). We have analyzed the main characteristics of the most frequent subtypes of BCC together with detailed head and neck site data recorded during 2 years.

MATERIAL AND METHODS

Ninety-five facial basal cell carcinoma patients were admitted to the Dermatology Clinic of Çankırı State Hospital between January 2011 and November 2012. Our hospital is a secondary health centre in Çankırı which is a province in the Central Anatolia Region of Turkey. The patients were evaluated retrospectively and demographic data, history of disease, clinical findings were collected from medical records The pathology slides were classified into one of six following histopathological subtypes: nodular, micronodular, superficial, infiltrative, solid, and adenobasal BCC (Figure 1a-1g) We used the histological parameters as described in World Health Organization (WHO) for the identification the histopathological subtype of BCCs (7).

In cases of mixed architecture combining features of superficial lobules plus large areas of

nodular BCC, the slides were classified as nodular BCCs. Cases with only a small zone of dermal nodular carcinoma in a large superficial carcinoma were classified in the superficial group. We also checked all data to rule out the possibility of including both a biopsy and a following surgical excision of the same tumor. We used the term nodular BCC when tumor cell clusters showing typical peripheral palisading were present in the dermis. The term superficial BCC was used to define a tumor including buds and irregular proliferations of tumor cells usually attached to an atrophic epidermis, with little or no penetration into the dermis. Basaloid cells arranged as elongated strands, only a few layers thick and with little or no palisading peripheral cells referred to as the infiltrative type of BCC.

Patient data included sex, age at diagnosis, and relevant medical history; tumor data included date at diagnosis and anatomic tumor site were derived from patient records. Multiple tumors per patient were included. These were defined as more than one tumor at the same time at whatever anatomic site, or new tumors that were observed and diagnosed at sites other than the primary tumor site. Recurrent tumors were excluded. We chose the tumors just located at head and neck and classified as follows: forehead, nose, cheek, ear- neck and periocular.

Statistical analysis

Descriptive data are presented as number (percentage) of cases. Comparisons between sex and age groups were performed using the chi-square test or Fisher exact test for categorical variables and the nonparametric Mann-Whitney U test for continuous variables. The association between histopathological subtype and anatomic location was tested using the Kruskal-Wallis test. A multiple comparison test was fitted to assess the independent association between histopathological subtype and anatomic location, adjusting for sex and age. P 0.05 was considered to indicate statistical significance (two-sided test). SPSS software, version 15.0 was used for the statistical analysis.

RESULTS

During the 2-year study period there was a total of 95 recorded patients with histopathologically confirmed BCC. Sex ratio was almost similar with a slight male predominance (F/M: 46/49) and the mean ± SD age at excision of a BCC was 69.98 ± 13.07 years. The nodular BCC was the most frequently occurring type (23.2%), followed by the superficial and micronodular types (22.1%). The micronodular, nodular and superficial BCC occurred more often in males and solid and infiltrative types more often in females. The adenobasal type was seen about equally among the sexes (Table 1).

All types of BCC were similar when compared with the localization. Almost all types showed slight predominance for nose localization. The superficial type was the dominant type on the cheek (Table 2). Figure (2a-2f). The mean tumor diameter is 8.94 mm with the range of 0.5-38 mm. There was a statistically significant difference between the micronodular with the smaller diameter of 5.25 mm and the other types of BCC diameter with the p value p=0.01. Epidermal ulceration was observed in most of the patients (77.9%) and there was not any significant difference in the types of BCC (Table 3).

There was a significant difference between the face-site distribution and sex. The localization of forehead was dominant in females (76.5%) while the cheek and ear- neck localization showed male predominance (36%, 18.2%). And for the nose localization females were dominant (57.6%) while ear-neck showed male predominance (81.8%) (Table 4). There was a significant difference between the face-site distribution and age, the patients with periocular BCC were younger than others (p<0.05). There was not any significant difference between the tumor localization and tumor diameter, and tumor localization and epidermal ulceration.

DISCUSSION

As in previously published works, our results are based on a retrospective study that included all consecutive cases from a single laboratory: this is the unique centre for dermatopathology in our geographical area. Neither dermatopathology nor clinical textbooks provide extensive information on the differences in age, gender and anatomical distribution of each histological subtype of BCC. Until 1990, most studies focused on the invasiveness and recurrence rates of the various subtypes. Large studies dealing with the demographic characteristics of the histological subtypes were published only after 1995 (16-18). Based on the eight largest studies previously published in the literature, (16-23) nodular BCCs comprised between 62% and 70% of all BCCs, except in the series from New Zealand (22), in which the nodular type accounted for only 47% of all BCCs. Superficial BCCs comprised 9-17.5% and morphoeiform BCCs 0.5-16.6% of carcinomas in those series. It is difficult to make rigorous comparisons between the published studies, mainly because the definition of subtypes varies from one study to another. This is especially true for morphoeiform carcinomas. Variations in inclusion criteria could probably account for part of the differences in distribution of BCC subtypes observed in those studies. Latitude and the resulting sun exposure could be another cause of variation in histological subtype. Our results are similar with the published material. As the results of our study nodular BCC was the most frequently occurring type (23.2%), followed by the superficial and micronodular types (22.1%). This result was consistent with the reports of Aandani and Ganatra and Cigna et al. and Janjua and Qureshi who also reported that nodular type was the most common type of the facial BCCs.

This study confirms that there are slight differences between tumor localization on the head and, sex and age distribution. Superficial BCC were more often found in males and preferentially developed on the cheek localization while other types preferring the nose. Like in our study, Peres et al, Heckmann et al. and Janjua and Qureshi. reported that nose is the most involved area with facial BCC (23). The micronodular, nodular and superficial BCC occurred more often in males and solid and infiltrative types are more often in females. The adenobasal type was seen about equally among the sexes.

These results suggest that the different histological types are not simple architectural variants, but rather correspond to different subsets of tumors. In the study that was carried on by Scrivener et al. it is mentioned that the superficial BCCs was 3 years lower than that of patients with nodular BCCs (24).

In the published reports on this subject, most authors claim that the etiology between superficial BCC and the other subtypes differs, as was suggested by Maccormack et al. (25 ); intermittent and probably also intense sun exposure are the best known risk factors for BCC (24,2-5). Superficial BCC occur predominantly on the trunk. Because the trunk is not continuously exposed to sunlight, intermittent sun exposure may be especially important in the etiology of superficial BCC (19,24). On the other hand, nodular BCC most frequently occur in the head/neck region, and occur more often in men on the ears and scalp, sites that are often not covered by hair. A much higher BCC density on the ears in males as compared with females was also found by others (26). In the present study we evaluated just the tumors on head and neck localization and could not carried out more investigation on sun exposure effects. All types of BCC were similar when compared with localization. Almost all types showed slight predominance for nose localization as previously published in the studies of Chow et al. Janjua and Qureshi. We found that the superficial type most commonly occurred on the cheek although Janjua and Qureshi reported that it was most commonly seen on the lower eyelid We also determined significant difference between the face- site distribution and sex. The localization of forehead females (76.5%) was dominant while the cheek and ear- neck localization showing male predominance (36%, 18.2%). And for the nose localization females were dominant (57.6%) while at ear-neck showed male predominance (81.8%). We also experienced that there was a significant difference between the face- site distribution and age; the patients with perioculer BCC were younger than others. There was not any significant difference between the tumor localization and tumor diameter, and tumor localization and epidermal ulceration.

Our study differs from the others with evaluating the tumor diamater and, epidermal ulceration. The mean tumor diameter is 8.94 mm with the range of 0.5-38 mm. There was a statistically significant difference between the micronodular with the smaller diameter of 5.25 mm and the other types of BCC diameter with the p value p=0.01. Epidermal ulceration was observed most of the patients (77.9%) and there was not any significant difference in the types of BCC.

Although our results confirmed those of the previous reports in the literature, large population sized studies should be required to clarify the exact distrubition of less common types of BCC of the head and neck region such as superficial variant.

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