Atherosclerosis Subclinical Progression

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Atherosclerosis Subclinical Progression


A dietary and exercise intervention slows menopause-associated progression of subclinical atherosclerosis as measured by intima-meia thickness of the carotid arteries


Article: A dietary and exercise intervention slows menopause-associated progression of subclinical atherosclerosis as measured by intima-meia thickness of the carotid arteries

Hypothesis: Effects of menopause and a diet or exercise intervention on subclinical atherosclerosis progression over a time interval of 4 years.

Methods: Brief outline of the study and design:

Intima-media thickness (IMT) measures of common carotid artery (CCA). Internal carotid artery (ICA) and bulb fragments of the blood vessels (arteries) were precisely measured twice throughout the itinerary of 4 years in 353 women from the Women’s Healthy Lifestyle Project, a dietary and exercise quantifiable experiment premeditated to prevent unfavorable hazardous aspect adjustments during menopause. A third determination was attained 2.5 years afterwards for 113 women.

  • Revision of the inhabitants [1991-1994, 535 women age 44-50 years (90% Caucasian)]
  • Medical procedures [review to revision baseline of each follow-up appointment]
  • Carotid Ultrasound [preliminary carotid examine were preformed on 453 women, a typical of 2.7 years from the baseline WHLP examination]
  • Statistical or Numerical Analysis

Results: The most important result(s) that tests the hypothesis was, the variables were found to be significantly associated with risk of subclinical atherosclerosis has been associated to elevated rates of coronary heart syndrome (disease), myocardial contravention and stroke and is considered an originator to scientific and medical cardiovascular events. The progression of ITM was observed for the average of all subdivisions (AVG), the CCA, and the bulb, but not for ICA. Along with the control group menopause was linked and associated with accelerated IMT progression. In addition, in the midst of the 160 perimenopausal/ postmenopausal women, the intercession slows the IMT succession and development. Comparable outcomes were established for the CCA and bulb fragments. Annual alteration was not drastically unusual between the intercession (intervention) and control groups. Intercession examination was stratified by menopause conditions to see the intervention achievement evidently lacking variation or alteration by menopause.


a. The hypothesis was supported by the results because the data demonstrated that the menopause change is linked by means of accelerated subclinical atherosclerosis succession as well as a diet/exercise intrusion leisurely menopause-correlated atherosclerosis development.

b. The medical implication(s) found in this study is indicative verification that the elevated predominance of the menopause evolution is possibly interrelated to improve development rates in the course of undeviating effects varying hormones on the vasculature. The modification in the cardiovascular hazard aspects in the menopausal change shared with hormonal effects on the vasculature possibly will create an atmosphere in which the vasculature is further prone to the progression of atherosclerosis. The WHLP has established that a diet and exercise interference effectively and successfully prevents the undesirable risk-factor transformed that escorts the menopause alteration.